This book discusses the physical properties of noble fluids, operational principles of detectors based on these media, and the best technical solutions to the design of these detectors. Essential attention is given to detector technology: purification methods and monitoring of purity, information readout methods, electronics, detection of hard ultra-violet light emission, selection of materials, cryogenics etc. The book is mostly addressed to physicists and graduate students involved in the preparation of fundamental next generation experiments, nuclear engineers developing instrumentation for national nuclear security and for monitoring nuclear materials.