In today’s competitive economy, companies often augment in-house production by outsourcing chemical reaction processes and distillation, drying, formulating, blending, and packaging operations. While most of these tolling, or contracted manufacturing services, proceed without incident, recent major accidents have pointed to weaknesses in some tolling arrangements, such as reactivity of materials and processes. This Guidelines book provides the reader with proven procedures to improve process safety throughout the life cycle of a contracted manufacturing operation. Extensive checklists and examples used throughout the book make it a valuable learning tool and reference for companies conducting toll manufacturing, or considering outsourcing manufacturing operations.